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4F-PHP has the official and systematic IUPAC name 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)hexan-1-one, a relative molar mass of 263.35 grams, and the empirical formula C16H22FNO.
4F-PHP may alternatively be referred to as 4-fluro-pyrrolidinohexiophenone. It is an analogue of the molecule alpha-pyrrolidinohexiophenone with 4F-PHP, which differs from its parent compound by having the aromatic ring fluorinated in the para position.
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Fluorination of medicinal compounds can occasionally increase bioavailability and lipophilicity, and the strongly electronegative nature of fluorine can affect the topographical charge of the molecule, interfering with metabolism and extending the compound’s half life. The electronegative fluorine atom should make the carbonyl less polar, reducing the compound’s reactivity.
4F-PHP belongs to the group of compounds known as substituted cathinones.
The substituted cathinones are a class of chemicals that have a phenethylamine backbone with a ketone at the beta carbon and various alkyl moieties replaced at the alpha carbon next to the amine. 4F-PVP and α-PHP have a butyl replacement at the alpha carbon. This increases the lipophilicity of these particular cathinones. The nitrogen itself is converted into a pyrrolidine molecule as it creates a five-member ring with four additional carbons.
When ingested, many cathinone chemicals have stimulant properties. Some generate euphoria, while others serve as entactogens. They are connected to the chemical molecule cathinone, derived from the plant Khat, which is native to the horn.
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Khat is an ethnobotanical having a long history of use among indigenous peoples. Chewing on the leaf released the cathinone chemical, which produced the intended pleasurable stimulatory effect. Substituted cathinones, on the other hand, have been used by humans for substantially shorter periods of time, with substances such as mephedrone and methylone being documented only in the last 15 years. These compounds grew in popularity due to their availability online and purported effects similar to classic psychoactives such as cocaine, MDMA, and amphetamine.
As legislation restricts the sale of these chemicals, new substituted cathinones such as MDPV, α-PVP, α-PHP, and 4F-PVP have arisen. Changes in structure can produce significant differences in perceived effects, duration of action, side effects, and toxicity.
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Because of the large number of new cathinones, there is frequently a lack of information about the effect profiles of many members of this family of pharmaceuticals. To try to get around legislation, changes are made on a regular basis.
α-PHP, a close relative of 4F-PHP, was shown to be an effective stimulant that caused a rush, alertness, and euphoria. Due to the similarities, 4F-PHP may have similar consequences.
4F-PHP is a very novel chemical. As a result, no research has been conducted on the pharmacological and toxicological profile of this chemical, as well as its possibly harmful consequences when administered to humans.
This chemical is not suitable for eating by animals or humans.
Subjective and unverifiable web reports claim that this chemical is reasonably powerful and generates euphoria.